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KMID : 0363819950290010048
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Korean Journal of Nuclear Medicine
1995 Volume.29 No. 1 p.48 ~ p.53
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A Study on the Estimation of Regional Myocardial Blood Flow in Experimental Canine Model with Coronary Thrombosis using Rb-82 Dynamic Myocardial Positron Emission Tomography
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곽철은
이동수/강건욱/황은경/정재민/장기현/정준기/이명철/서정돈
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Abstract
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This study investigates a simple mathematical model for the quantitative estimation of regional myocardial blood flow in experimental canine coronary artery thrombosis using Rb-82 dynamic myocardial positron emission tomography. The coronary
thrombosis
was induced using the new catheter technique by narrowing the lumen of coronary vessel gradually, which finally led to partial obstruction of coronary artery. Ten Rb-82 dynamic myocardial PET scans were performed sequentially for each experiment
using
our 5, 10 and 20 second acquisition protocol, respectively, and three regions of interest were drawn on the transaxial slices, one on left ventricular chamber for input function and the other two on normal and decreased perfusion segments for the
flow
estimation in those regions. Single compartment model has been applied to the measured sets of regional PET data, and the rate constants of influx to myocardial tissue were calculated for regional myocardial flow estimates with the three
parameter
fits
of raw data by the Levenberg-Marquardt method. The results showed that, (1) single compartment model suggested by Kety-Schmidt could be used for the simple estimation of regional myocardial blood flow, (2) the calculated regional myocardial blood
flow
estimates were dependent on the selection of input, which reflected partial volume effect and left ventricular wall motion, and (3) mathematically fitted input and tissue time activity curves were more suitable than the direct application of the
measured data in terms of convergence.
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KEYWORD
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